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Video: University of Michigan School of Public Health

Navigating the COVID-19 pandemic with young children is challenging. Parents struggling to discuss the pandemic with their children can find help in a video from the University of Michigan School of Public Health that provides scientifically accurate information about COVID-19 for children 6 to 11 years old.

Narrated by a child, the video provides information on the current knowledge about COVID-19 and recommends public health methods for personal and community protection. The video is intended to encourage families to talk "constructively about the virus and the way it has impacted their lives," according to a press release.

"This video is scientifically accurate while taking into account not only a child's intellectual curiosity but also their emotional needs as they approach a difficult and increasingly personal subject matter," Alison Miller, of the University of Michigan School of Public Health, said in a statement.

Learn more on the University of Michigan School of Public Health site.

Experts share their tips on how to prevent misbehavior in kids and teens.

6 Expert Tips for Defusing Kids' Quarantine Meltdowns

TUESDAY, May 26, 2020 (HealthDay News) -- When kids and teens chafe under COVID-19 quarantine, how can parents stop the meltdowns and misbehavior?

Start with understanding: Young people miss their friends and their freedom. Younger kids might respond by throwing tantrums. Teens might isolate themselves, ignore social distancing rules or sneak out to see friends.

To curb negative behavior, experts from Penn State Children's Hospital offer their advice.

Read the full HealthDay story.

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Hydroxychloroquine or chloroquine with or without macrolides is linked to in-hospital mortality and arrhythmia.

Hydroxychloroquine Plus Macrolides No Benefit in COVID-19

TUESDAY, May 26, 2020 (HealthDay News) -- For patients with COVID-19 requiring hospitalization, there is no evidence of benefit for use of hydroxychloroquine or chloroquine with or without a macrolide, according to a study published online May 22 in The Lancet.

Mandeep R. Mehra, M.D., from the Brigham and Women's Hospital Heart and Vascular Center in Boston, and colleagues conducted a multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without macrolides for COVID-19 treatment. A total of 96,032 patients hospitalized at 671 hospitals in six continents between Dec. 20, 2019, and April 14, 2020, were included. They were classified into four treatment groups (1,868 received chloroquine; 3,783 received chloroquine with a macrolide; 3,016 received hydroxychloroquine; and 6,221 received hydroxychloroquine with a macrolide) and a control group (81,144 patients).

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Right ventricular enlargement significantly linked to in-hospital mortality in multivariable analysis.

Right Ventricular Dilation Linked to Mortality in COVID-19

TUESDAY, May 26, 2020 (HealthDay News) -- Right ventricular dilation is associated with in-hospital mortality among patients hospitalized with COVID-19, according to a study published online May 15 in JACC: Cardiovascular Imaging.

Edgar Argulian, M.D., M.P.H., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues enrolled consecutive patients hospitalized due to COVID-19 who underwent clinically indicated echocardiograms from March 26 to April 22, 2020. The associations between clinical and echocardiographic variables and mortality were explored.

Echocardiograms of 110 patients were reviewed, with five excluded due to inadequate study quality. The researchers found that at the time of echocardiographic examination, 31 patients were intubated and mechanically ventilated. Thirty-two patients (31 percent) had right ventricular dilation. Patients with right ventricular dilation were more likely to have renal dysfunction than those without right ventricular dilation, but there were no significant differences noted in the prevalence of major comorbidities, laboratory markers of inflammation, or myocardial infarction. Patients with right ventricular enlargement had a higher prevalence of right ventricular hypokinesis and moderate or severe tricuspid regurgitation. Five of 10 patients with right ventricular enlargement who underwent computed tomography angiography of the chest had evidence of pulmonary embolism. During the study period, 21 patients died: 13 and eight (41 and 11 percent) patients with and without right ventricular dilation, respectively. Right ventricular enlargement was the only variable significantly associated with mortality in a multivariable analysis (odds ratio, 4.5).

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A new study says the antiviral drug on its own won't be enough to significantly curb COVID-19 cases and deaths. There are several dual-drug trials already underway to see if remdesivir paired with another drug could help boost outcomes.

Remdesivir Will Not Be Enough to Curb COVID-19, Study Finds

SATURDAY, May 23, 2020 (HealthDay News) -- There have been high hopes that the antiviral drug remdesivir might be an answer to the pandemic of COVID-19. But a major, new study finds the drug on its own won't be enough to significantly curb cases and deaths.

The study, published May 22 in the New England Journal of Medicine, found that, "given high mortality [of patients] despite the use of remdesivir, it is clear that treatment with an antiviral drug alone is not likely to be sufficient."

Read the full HealthDay story.

The American Psychological Association offers some tips on ways of coping with loss and grief.

How to Cope With Your Grief During Coronavirus Pandemic

FRIDAY, May 22, 2020 (HealthDay News) -- Grief is touching the lives of countless Americans as the COVID-19 death toll mounts.

The death of a family member or close friend can be among the most difficult things you'll have to deal with, so the American Psychological Association outlines ways of coping with that loss -- whether or not it is coronavirus-related.

Talking about the death with friends or others can help you understand what happened and remember that person. Avoiding the issue can lead to isolation and interfere with the healing process.

You may experience a wide range of emotions -- from sadness, anger or even exhaustion -- and should accept them, the APA says in a news release.

Read the full HealthDay story.

Some common stressors included managing distance/online learning for their kids, providing basic needs like access to food and housing and being upset about missing major milestones.

Pandemic Has Overburdened Parents Stressed Out: Poll

FRIDAY, May 22, 2020 (HealthDay News) -- If there's such a thing as a "new normal" during the coronavirus pandemic, it's a constant state of stress.

And it's particularly intense for many parents who are keeping house, working from home, and trying to keep their kids' online learning on track at the same time, according to a new online survey.

Nearly half (46%) of respondents who have kids younger than 18 said their average stress level is high these days. Only 28% of adults without minor children said the same, according to the online poll of more than 3,000 adults. It was conducted from April 24 to May 4.

Read the full HealthDay story.

The only factors independently associated with time to extubation are age and body mass index.

Age, Sex, History of Diabetes Predict Intubation in COVID-19

FRIDAY, May 22, 2020 (HealthDay News) -- Older age, male sex, and history of diabetes are factors predictive of intubation among hospitalized patients with COVID-19, while age and body mass index are associated with time to extubation, according to a study published online May 19 in Otolaryngology-Head and Neck Surgery.

Kevin Hur, M.D., from the Feinberg School of Medicine at Northwestern University in Chicago, and colleagues examined sociodemographic and clinical characteristics associated with intubation and prolonged intubation for acute respiratory failure secondary to COVID-19 infection among 486 patients admitted between March 1 and April 8, 2020.

The researchers found that 55.8 percent of the patients were male and the median body mass index was 30.6 kg/m². Overall, 28.4 percent of patients were intubated during the hospitalization; 56.5 percent of these patients were eventually extubated, while 15.2 percent died and 28.3 percent remained intubated at a median follow-up of 19.6 days. Compared with nonintubated patients, intubated patients had a significantly higher median age (65 versus 57 years) and higher rate of diabetes (40.6 versus 29.9 percent). Age, sex, respiratory rate, oxygen saturation, history of diabetes, and shortness of breath were identified as factors predictive of intubation. The only factors independently associated with time to extubation were age and body mass index.

Read the full HealthDay story.

Corita Grudzen, M.D., of the Ronald O. Perelman Department of Emergency Medicine, spoke with HealthDay Live! about the trial.

Convalescent Plasma Trial for COVID-19 Patients Underway at NYU Langone

THURSDAY, May 21, 2020 (HealthDay News) -- Researchers at the NYU Grossman School of Medicine are conducting a phase II clinical trial to determine the efficacy of convalescent plasma in hospitalized patients with COVID-19. Corita R. Grudzen, M.D., vice chair for research in the Ronald O. Perelman Department of Emergency Medicine at NYU Langone Health, wrote the study protocol and recently spoke with HealthDay Live! about the trial.

"What we hope to see is that convalescent plasma used in this stage of disease prevents patients from dying, going on a mechanical ventilator," or being admitted to the intensive care unit, Grudzen said.

The controlled, randomized trial, which started April 17 and is also being led by researchers from Montefiore Health System and Albert Einstein College of Medicine, will enroll 300 hospitalized patients ages 18 years or older from seven hospital centers. The researchers are enrolling patients within three to seven days after symptom onset. While other studies across the country are focusing on sicker populations, Grudzen said the research team felt strongly about enrolling hospitalized patients. "We know the earlier, the better," she said. As an emergency physician, she said, "many of us were seeing hundreds and now thousands of patients hospitalized, and so we really wanted to focus on that group. We know historically [that] the antibody binds to the virus in some way to prevent it from either entering the cells or from destroying whomever it's attacking. And so, the idea is to do that before there's an onslaught of the body's own inflammatory response."

Read the full HealthDay story.

Doctors reported that a teenager in Italy presented with the first known case of thyroiditis caused by the new coronavirus.

Coronavirus Can Infect, Inflame the Thyroid

FRIDAY, May 22, 2020 (HealthDay News) -- An Italian teenager may be the first known case of a painful thyroid infection caused by the new coronavirus, doctors report.

A research team from Pisa, in northern Italy, said the 18-year-old woman's thyroid became sore and enlarged a few weeks after testing positive for the SARS-CoV-2 virus in late February. The condition, called thyroiditis, cleared up completely within a week after she was treated with the steroid prednisone.

Still, the doctors believe that "physicians should be alerted about the possibility of this additional clinical manifestation" tied to the new coronavirus, study leader Dr. Francesco Latrofa, an endocrinologist at the University Hospital of Pisa, said in a news release from the Endocrine Society. He and his colleagues published the findings May 21 in The Journal of Clinical Endocrinology & Metabolism.

Read the full HealthDay story.