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Each week, HealthDay's Physician's Briefing division rounds up the most important COVID-19 developments in the medical field. See this week's edition below for April 13th-April 17th.

Asthma Not Common in COVID-19 Patients Who Have Died

FRIDAY, April 17, 2020 (HealthDay News) -- Asthma is not among the top 10 chronic health problems in people who have died from coronavirus disease 2019 in New York state, even though many health experts have warned that people with asthma are at increased risk for severe illness if they get COVID-19.

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Insomnia Common Among Medical Staff During COVID-19 in China

FRIDAY, April 17, 2020 (HealthDay News) -- More than one-third of medical staff members in hospitals during the coronavirus disease 2019 outbreak in China reported insomnia symptoms, according to a study published online April 14 in Frontiers in Psychiatry.

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Incidence of SARS-CoV-2 Infection Stable in Iceland

FRIDAY, April 17, 2020 (HealthDay News) -- In Iceland, the incidence of severe acute respiratory syndrome coronavirus 2 infection was stable through 20 days of screening, according to a study published online April 14 in the New England Journal of Medicine.

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CDC Looks at Transmission of COVID-19 to Health Care Workers

FRIDAY, April 17, 2020 (HealthDay News) -- Transmission of coronavirus disease 2019 to health care personnel is explored in two studies published in the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Chest X-Ray Findings Normal for Many Confirmed COVID-19 Cases

FRIDAY, April 17, 2020 (HealthDay News) -- Most patients presenting to urgent care centers with confirmed coronavirus disease 2019 have normal or mildly abnormal findings on chest X-rays, according to a study published online April 14 in the Journal of Urgent Care Medicine.

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IDSA Issues Rapid Guidelines for Treatment of COVID-19

FRIDAY, April 17, 2020 (HealthDay News) -- In rapid guidelines issued by the Infectious Diseases Society of America, recommendations are presented for the treatment and management of coronavirus disease 2019.

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Risk for Severe COVID-19 May Be Up in People With COPD, Smokers

FRIDAY, April 17, 2020 (HealthDay News) -- Active cigarette smokers and individuals with chronic obstructive pulmonary disease have up-regulation of angiotensin converting enzyme II expression in the lower airways, which could explain the increased risk for severe COVID-19 in these subpopulations, according to a study published online April 8 in the European Respiratory Journal.

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CRISPR-Based Test Can Diagnose COVID-19 in Under 60 Minutes

THURSDAY, April 16, 2020 (HealthDay News) -- Researchers say they have developed a low-cost swab test that can diagnose coronavirus disease 2019 infections in about 45 minutes.

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FDA Urges COVID-19 Survivors to Donate Plasma

THURSDAY, April 16, 2020 (HealthDay News) -- The U.S. Food and Drug Administration is asking Americans who have recovered from coronavirus disease 2019 to donate their blood plasma to help fight the pandemic.

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Scientists Design Protective Respirator for Health Care Workers

THURSDAY, April 16, 2020 (HealthDay News) -- With protective gear in short supply, Duke University researchers say they have designed a much-needed respirator for health care workers battling coronavirus disease 2019.

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Sharp Drop in Demand Seen for COVID-19 Tests at Private Labs

THURSDAY, April 16, 2020 (HealthDay News) -- There has been such a drop in demand for coronavirus disease 2019 tests at private labs in the United States that they have "considerable" unused capacity and can test more patients with less severe symptoms, the American Clinical Laboratory Association says.

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Recurrent Winter Outbreaks of SARS-CoV-2 Projected

THURSDAY, April 16, 2020 (HealthDay News) -- Recurrent winter outbreaks of severe acute respiratory syndrome-coronavirus-2 are projected to occur after the initial pandemic wave, according to a study published online April 14 in Science.

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Surgery Department Outlines Rapid Response to COVID-19

THURSDAY, April 16, 2020 (HealthDay News) -- In a comprehensive rapid response plan, published online April 9 in the Journal of the American College of Surgeons, surgeons from the University of California San Francisco present a strategy to triage surgeries to help manage health care resources during the coronavirus disease 2019 pandemic.

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Guidance Issued for Breast Cancer Care During COVID-19

THURSDAY, April 16, 2020 (HealthDay News) -- In guidance issued by the COVID-19 Pandemic Breast Cancer Consortium, recently accepted for publication in an upcoming issue of Breast Cancer Research and Treatment, recommendations are presented for prioritizing care for breast cancer patients during the coronavirus disease 2019 pandemic.

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Guidance Developed for Treating Cardiac Arrest During COVID-19

THURSDAY, April 16, 2020 (HealthDay News) -- In a document entitled "Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19," published online April 9 in Circulation, recommendations are presented for treating victims of cardiac arrest during the coronavirus disease 2019 pandemic.

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Telehealth Usage Was Growing Among Internists Prior to COVID-19

THURSDAY, April 16, 2020 (HealthDay News) -- There is wide variation in the use of telehealth among internal medicine physicians and subspecialists, according the "2020 American College of Physicians Member Survey About Telehealth Implementation."

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Obesity Is Risk Factor for COVID-19 Hospital Admission in <60s

WEDNESDAY, April 15, 2020 (HealthDay News) -- Obesity is associated with admission to the hospital for coronavirus disease 2019 patients, according to a study published online April 9 in Clinical Infectious Diseases and a study not yet peer reviewed and posted on medRxiv.org.

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Survey Shows Lack of COVID-19 Concern Even Among Those at Risk

WEDNESDAY, April 15, 2020 (HealthDay News) -- Many individuals at greater risk for coronavirus disease 2019 complications did not believe the virus would affect them at the beginning of Chicago's outbreak, according to a study published online April 9 in the Annals of Internal Medicine.

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Compliance With Self-Isolation Influenced by Compensation

WEDNESDAY, April 15, 2020 (HealthDay News) -- In the era of coronavirus disease 2019, compliance with self-isolation is influenced by compensation, with very high compliance seen when compensation for lost wages is assured, according to a report published online April 9 in Health Affairs.

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SARS-CoV-2 Contamination of Air, Surfaces Examined in ICU, Wards

WEDNESDAY, April 15, 2020 (HealthDay News) -- Considerable severe acute respiratory syndrome coronavirus-2 contamination of air and object surfaces is reported in intensive care units and general coronavirus disease 2019 wards, according to a study published online April 10 in Emerging Infectious Diseases, a publication of the U.S. Centers for Disease Control and Prevention.

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Public Health Interventions Improved COVID-19 Control in Wuhan

WEDNESDAY, April 15, 2020 (HealthDay News) -- Multifaceted public health interventions improved control of the coronavirus disease 2019 outbreak in Wuhan, China, according to a study published online April 10 in the Journal of the American Medical Association.

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Common Coronaviruses Are Highly Seasonal

WEDNESDAY, April 15, 2020 (HealthDay News) -- Common coronaviruses circulate seasonally, according to a study published online April 4 in the Journal of Infectious Diseases.

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Intubation Initiated in One in Five Who Died of COVID-19 in China

WEDNESDAY, April 15, 2020 (HealthDay News) -- Many patients who died from coronavirus disease 2019 in China may have had delayed intubation, according to a research letter published online April 10 in JAMA Network Open.

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First Saliva Test for COVID-19 Approved by FDA

TUESDAY, April 14, 2020 (HealthDay News) -- The first saliva test for coronavirus 2019 was approved Monday by the U.S. Food and Drug Administration.

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U.S. Government Says COVID-19 Antibody Tests Must Be Free

TUESDAY, April 14, 2020 (HealthDay News) -- Health insurers and Medicaid must provide free coverage for tests to detect coronavirus 2019 antibodies in people who have been infected, the federal government says.

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CDC: Public Policy Measures Important for Social Distancing

TUESDAY, April 14, 2020 (HealthDay News) -- Community mobility in four metropolitan areas decreased with the introduction of public policy measures supporting social distancing, which could help slow the spread of coronavirus disease 2019, according to research published in the April 13 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Smell, Taste Impairment Linked to COVID-19 Positivity

TUESDAY, April 14, 2020 (HealthDay News) -- Smell and taste impairment are strongly associated with coronavirus disease 2019 positivity, according to a study published online April 12 in the International Forum of Allergy & Rhinology.

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Review: Quarantine Effective for Reducing Infection, Death

TUESDAY, April 14, 2020 (HealthDay News) -- Quarantine is effective for reducing the number of people infected and deaths from coronavirus disease 2019, according to a review published online April 8 in the Cochrane Database of Systematic Reviews.

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Medical Masks May Be Sufficient During COVID-19 Routine Care

TUESDAY, April 14, 2020 (HealthDay News) -- Use of medical masks, such as surgical or procedural masks, does not increase the risk for viral infection or respiratory illness, and their use may serve as a protective measure in instances of N95 respirator shortages, according to the results of a meta-analysis published online April 4 in Influenza and Other Respiratory Viruses.

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First Wave of COVID-19 Abated With Control Measures in China

TUESDAY, April 14, 2020 (HealthDay News) -- Interventions implemented in China interrupted coronavirus disease 2019 transmission in all areas outside of Hubei, and low transmissibility can be maintained by monitoring the instantaneous effective reproduction number, according to a study published online April 8 in The Lancet.

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COVID-19 RNA Detectable in Patient Fecal Matter

TUESDAY, April 14, 2020 (HealthDay News) -- The presence of severe acute respiratory syndrome coronavirus 2 RNA is detectable in the feces of COVID-19 patients and remains even after negative conversion in pharyngeal swabs, according to a study published online April 3 in the Journal of Medical Virology.

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Model Forecasts When COVID-19 Demand Will Exceed Capacity

TUESDAY, April 14, 2020 (HealthDay News) -- The COVID-19 Hospital Impact Model, a publicly available tool, can help hospitals predict the timing of saturated capacity, according to a report published online April 7 in the Annals of Internal Medicine.

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COVID-19 Antibody Tests Underway in California

MONDAY, April 13, 2020 (HealthDay News) -- Large-scale studies of tests to check for antibodies to coronavirus 2019 are underway in California. The findings from this research could help the United States develop strategies to get people back to work and restart the economy.

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Chloroquine COVID-19 Trial Stopped After Patient Deaths

MONDAY, April 13, 2020 (HealthDay News) -- A study of chloroquine in coronavirus 2019 patients was halted due to potentially deadly side effects.

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Survey IDs Those Most Affected by One-Month COVID-19 Lockdown

MONDAY, April 13, 2020 (HealthDay News) -- Adults who stopped working during coronavirus 2019-related lockdowns in China report worse mental and physical health, according to a study published online April 4 in Psychiatry Research.

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Physicians Report Expanding Use of Off-Label COVID-19 Treatments

MONDAY, April 13, 2020 (HealthDay News) -- Hydroxychloroquine usage is expanding globally to treat coronavirus 2019, although plasma from recovered patients is perceived as more effective than hydroxychloroquine, according to a report released by Sermo.

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Remdesivir May Improve Oxygen-Support Class in Severe COVID-19

MONDAY, April 13, 2020 (HealthDay News) -- Improvement in oxygen support status was observed in 68 percent of patients hospitalized with severe coronavirus disease 2019 who received compassionate use of remdesivir, according to a study published online April 10 in the New England Journal of Medicine.

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CDC Report Details Geographic Variation in U.S. COVID-19 Cases, Deaths

MONDAY, April 13, 2020 (HealthDay News) -- There is variation in the cumulative incidence of coronavirus disease 2019 across jurisdictions in the United States, according to research published in the April 10 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Recommendations Issued for Use of Imaging in Adults With COVID-19

MONDAY, April 13, 2020 (HealthDay News) -- In a multinational consensus statement from the Fleischner Society, published online April 7 in Radiology, recommendations are presented for use of imaging in patients with coronavirus disease 2019.

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Mechanical Ventilation Needed by Most COVID-19 Patients in ICU

MONDAY, April 13, 2020 (HealthDay News) -- Most patients with coronavirus disease 2019 requiring treatment in an intensive care unit require mechanical ventilation, according to a study published online April 6 in the Journal of the American Medical Association.

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Guidance Issued for Infants Born to Mothers With COVID-19

MONDAY, April 13, 2020 (HealthDay News) -- In an initial guidance document issued by the American Academy of Pediatrics, recommendations are presented for the management of infants born to mothers with suspected or confirmed coronavirus disease 2019.

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Each week, HealthDay's Physician's Briefing division rounds up the most important COVID-19 developments in the medical field. See this week's edition below for July 6-July 10.

Gilead Presents Additional Data on Efficacy of Remdesivir for COVID-19

FRIDAY, July 10, 2020 (HealthDay News) -- There is more good news on the effectiveness of the antiviral drug remdesivir against COVID-19, according to new clinical trial results from the drug's maker.

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Risk for COVID-19 Increased for Adults Taking PPIs

FRIDAY, July 10, 2020 (HealthDay News) -- Adults taking proton pump inhibitors have an increased risk for having a positive COVID-19 test, with evidence of a dose-response relationship, according to a study published online July 7 in preprint format in the American Journal of Gastroenterology.

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WHO to Lead Investigation of COVID-19 Pandemic Origins

FRIDAY, July 10, 2020 (HealthDay News) -- The World Health Organization will lead an international investigation into the origins of the COVID-19 pandemic in China.

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Emphasizing Severity of COVID-19 Important for Teen Behaviors

FRIDAY, July 10, 2020 (HealthDay News) -- For adolescents, understanding the severity of COVID-19 and valuing social responsibility are associated with acting in socially responsible ways, including more social distancing and disinfecting, according to a study published online June 29 in JAMA Pediatrics.

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Children Seem Not to Be Driving SARS-COV-2 Transmission

FRIDAY, July 10, 2020 (HealthDay News) -- Children are mainly infected with severe acute respiratory syndrome coronavirus 2 in familial clusters, suggesting that transmission in schools is likely to be less than expected and that school closures are not necessary, according to a study and accompanying editorial published online July 10 in Pediatrics.

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COVID-19 Explored in Kidney Recipients, Hemodialysis Patients

FRIDAY, July 10, 2020 (HealthDay News) -- Many outpatient kidney transplant recipients with COVID-19 have symptomatic resolution without requiring hospitalization, and hospitalized COVID-19 patients on hemodialysis have worse outcomes than those without kidney failure, according to two studies recently published in the Clinical Journal of the American Society of Nephrology.

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Incidence of Takotsubo Cardiomyopathy Up During COVID-19

FRIDAY, July 10, 2020 (HealthDay News) -- The incidence of Takotsubo cardiomyopathy has increased during the COVID-19 pandemic, according to a study published online July 9 in JAMA Network Open.

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Sick Days Up for Some Essential Workers During COVID-19

THURSDAY, July 9, 2020 (HealthDay News) -- Increases in health-related workplace absenteeism were seen in April 2020 in personal care and service, health care support, and production occupations, according to research published in the July 10 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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COVID-19 Pandemic Exacerbates Mental Health Issues

THURSDAY, July 9, 2020 (HealthDay News) -- Just as the physical symptoms of COVID-19 vary among the population, mental health is enduring a variety of effects from the virus as well, according to Don Mordecai, M.D., national mental health and wellness lead at Kaiser Permanente, who recently spoke with HD Live! about the effects of the pandemic on mental health.

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Spectrum of Neurological Disorders Linked to SARS-CoV-2

THURSDAY, July 9, 2020 (HealthDay News) -- Severe acute respiratory syndrome coronavirus 2 infection is associated with a spectrum of neurological disorders, according to a study published online July 8 in Brain.

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CDC Updates Info on COVID-19 Cases at Meat, Poultry Processing Facilities

THURSDAY, July 9, 2020 (HealthDay News) -- COVID-19 was confirmed in 16,233 workers in 239 meat and poultry processing facilities in 23 states through May 31, 2020, according to research published in the July 7 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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February to March 2020 Saw Surge in Hydroxychloroquine Rx

WEDNESDAY, July 8, 2020 (HealthDay News) -- From February to March 2020, there was a considerable increase in the number of patients receiving outpatient prescriptions for hydroxychloroquine, chloroquine, and azithromycin, according to a research letter published online July 6 in JAMA Internal Medicine.

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Multisystem Inflammatory Syndrome in Children Profiled

WEDNESDAY, July 8, 2020 (HealthDay News) -- Multisystem inflammatory syndrome in children, which coincided with COVID-19, is described in children and adolescents in the United States and New York state in two reports published online June 29 in the New England Journal of Medicine.

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Rising Number of People Report Anxiety, Depression During COVID-19

WEDNESDAY, July 8, 2020 (HealthDay News) -- New evidence shows that depression and anxiety are increasing as a result of the COVID-19 pandemic, according to the results of a survey released by Mental Health America.

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COVID-19 Antibody Cocktail Begins Late-Stage Human Trials

TUESDAY, July 7, 2020 (HealthDay News) -- Late-stage human trials to assess whether a double antibody cocktail can prevent and treat COVID-19 infection have started, biotechnology company Regeneron said Monday.

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Company Gets $1.6 Billion From U.S. Government for COVID-19 Vaccine

TUESDAY, July 7, 2020 (HealthDay News) -- Vaccine maker Novavax will receive $1.6 billion from the U.S. government to provide 100 million doses of a COVID-19 vaccine by early 2021, the Maryland-based company said Monday.

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Acute Ischemic Stroke Risk Higher With COVID-19 Than Influenza

TUESDAY, July 7, 2020 (HealthDay News) -- Patients with COVID-19 appear to have a heightened risk for acute ischemic stroke compared with patients with influenza, according to a study published online July 2 in JAMA Neurology.

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Social Distancing Effective for Mitigating COVID-19 Spread

TUESDAY, July 7, 2020 (HealthDay News) -- Social distancing is one of the main measures to combat COVID-19 spread, according to a study published online July 1 in The Lancet Infectious Diseases.

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Chilblains in Recent Case Series Not Tied to COVID-19 Infection

TUESDAY, July 7, 2020 (HealthDay News) -- In a case series of 31 patients, published online June 25 in JAMA Dermatology, chilblains did not appear to be directly associated with COVID-19.

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Major Medical Groups Urge Americans to Wear Face Masks

MONDAY, July 6, 2020 (HealthDay News) -- Three major medical groups are urging Americans to wear face masks, wash their hands, and practice social distancing as COVID-19 cases continue to surge in the United States.

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Fight Against COVID-19 Threatens Progress Against Other Diseases

MONDAY, July 6, 2020 (HealthDay News) -- Decades of progress against HIV, tuberculosis, malaria, and other diseases worldwide are threatened by the diversion of resources on the COVID-19 pandemic, the International AIDS Society says in a report to be published this week.

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FDA Warns About Hand Sanitizers With Methanol

MONDAY, July 6, 2020 (HealthDay News) -- A warning about hand sanitizer products that contain methanol (wood alcohol), a substance often used to create fuel and antifreeze, has been issued by the U.S. Food and Drug Administration.

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Scientists Say New Coronavirus Can Linger in Indoor Air

MONDAY, July 6, 2020 (HealthDay News) -- The new coronavirus can linger in indoor air and infect people, 239 scientists in 32 countries say in an open letter to the World Health Organization that challenges the WHO's position on how the virus is spread.

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Endotheliopathy ID'd in COVID-19, Tied to Higher Mortality Risk

MONDAY, July 6, 2020 (HealthDay News) -- Endotheliopathy is present in COVID-19 and is associated with critical illness and death, according to a study published online June 30 in The Lancet Haematology.

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Outcomes Similar for COVID-19 in Patients With, Without HIV

MONDAY, July 6, 2020 (HealthDay News) -- Persons with HIV hospitalized with COVID-19 have similar outcomes to demographically matched patients without HIV, according to a study published online June 28 in Clinical Infectious Diseases.

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Most Using Online COVID-19 Tool Report Mild, Moderate Symptoms

MONDAY, July 6, 2020 (HealthDay News) -- The majority of individuals using an online COVID-19 self-assessment tool report mild or moderate symptoms possibly associated with COVID-19, according to research published online June 15 in the Journal of General Internal Medicine.

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HD Live! Videos

Our latest HD Live! discussion is on how countries have contained COVID-19 and whether the United States can do the same with universal masking and certain other health strategies.

Mabel Jong from our liveblog team speaks with Dr. Robert Brook, a professor of medicine at UCLA and the distinguished chair in the health care services program at the RAND Corporation, and Dr. May Chu, a clinical professor of epidemiology with the Colorado School of Public Health at the University of Colorado Anschutz Medical Campus.

Watch our in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

They contend that much smaller exhaled droplets can travel the length of a room and cause infection when inhaled.

Scientists Say New Coronavirus Can Linger in Indoor Air

MONDAY, July 6, 2020 (HealthDay News) -- The new coronavirus can linger in indoor air and infect people, 239 scientists in 32 countries say in an open letter to the World Health Organization that challenges the WHO's position on how the virus is spread.

The WHO says the virus is spread primarily by large respiratory droplets expelled by infected people in coughs and sneezes but that those droplets fall quickly to the floor instead of remaining in the air, The New York Times reported. But the scientists' letter contends that much smaller exhaled droplets can travel the length of a room through the air and cause infection when they are inhaled. They plan to publish their letter next week in a scientific journal.

If this type of airborne transmission plays a significant role in the pandemic, there are major implications, according to The Times. Masks may be required indoors, building ventilation systems may need to minimize recirculating air, ultraviolet lights may be required to kill airborne viral particles, and health care workers may need masks that filter out even the smallest respiratory droplets as they care for COVID-19 patients.

Read the full HealthDay story.

Methanol can be toxic when absorbed through the skin and life-threatening when ingested.

FDA Warns About Hand Sanitizers With Methanol

MONDAY, July 6, 2020 (HealthDay News) -- A warning about hand sanitizer products that contain methanol (wood alcohol), a substance often used to create fuel and antifreeze, has been issued by the U.S. Food and Drug Administration.

Methanol can be toxic when absorbed through the skin and life-threatening when ingested, and it is not an acceptable active ingredient for hand sanitizer products, according to the FDA. The agency said it has seen an increase in hand sanitizer products that are labeled to contain ethanol (also known as ethyl alcohol) but that have tested positive for methanol. Methanol exposure can result in nausea, vomiting, headache, blurred vision, permanent blindness, seizures, coma, permanent damage to the nervous system, or death.

State officials have reported recent harm among adults and children who ingested hand sanitizer products contaminated with methanol, including blindness, hospitalization, and death, the FDA said. Consumers who have hand sanitizers with methanol should immediately stop using them and dispose of the bottle in a hazardous waste container, if available, or dispose of it as recommended by their local waste management and recycling center. There is a list of FDA-tested and recalled hand sanitizers on the agency's website.

Read the full HealthDay story.

In many cities, a combination of factors are fueling the problem: a shortage of key supplies, backlogs at laboratories that perform the tests, and surging infection counts as cases climb in almost 40 states.

U.S. Coronavirus Cases Near 3 Million as Hospitals in Sun Belt Fill Up With Patients

TUESDAY, July 7, 2020 (HealthDay News) -- With the number of coronavirus cases in the United States approaching 3 million on Monday, hospitals across the Sun Belt continued to be flooded with COVID-19 patients.

Arizona reached 89 percent capacity for ICU beds, as Alabama, California, Georgia, North Carolina, South Carolina and Texas also reported unprecedented numbers of hospitalizations, the Washington Post reported.

For the 28th day in a row, the country's rolling seven-day average of daily new cases obliterated previous records, though the number of deaths nationwide has remained relatively stable, the newspaper reported.

Read the full HealthDay story.

Authors say self-assessment tool could ease burden on health care system and collect useful information.

Most Using Online COVID-19 Tool Report Mild, Moderate Symptoms

MONDAY, July 6, 2020 (HealthDay News) -- The majority of individuals using an online COVID-19 self-assessment tool report mild or moderate symptoms possibly associated with COVID-19, according to research published online June 15 in the Journal of General Internal Medicine.

William M. Mehring, from the Keck School of Medicine at the University of Southern California in Los Angeles, and colleagues developed a web-based COVID-19 self-assessment tool, available in English and Spanish, and report the results of 276,560 digital self-assessments.

The researchers report that of the 5,611 users who entered optional demographic data, 61 percent were female (mean age, 39 years). In more than two-thirds of self-assessments (69.6 percent), users reported symptoms potentially attributable to COVID-19. Among the reported symptoms potentially attributable to COVID-19, the majority (80.5 percent) reported mild or moderate symptoms that could likely be managed with home self-care, while 19.5 percent reported severe symptoms for which the tool recommended immediate medical attention. Of individuals reporting mild symptoms, 7.1 percent said they had direct exposure to someone with confirmed COVID-19.

Read the full HealthDay story.

Soluble thrombomodulin concentration >3.26 ng/mL linked to lower rates of hospital discharge and survival.

Endotheliopathy ID'd in COVID-19, Tied to Higher Mortality Risk

MONDAY, July 6, 2020 (HealthDay News) -- Endotheliopathy is present in COVID-19 and is associated with critical illness and death, according to a study published online June 30 in The Lancet Haematology.

George Goshua, M.D., from the Yale School of Medicine in New Haven, Connecticut, and colleagues conducted a single-center study involving hospitalized adult patients with laboratory-confirmed COVID-19 from the medical intensive care unit (ICU) or a specialized non-ICU COVID-19 floor (48 and 20 patients, respectively); 13 asymptomatic nonhospitalized controls were recruited as a comparator group. Markers of endothelial cell and platelet activations were assessed and the levels were compared for ICU patients, non-ICU patients, and controls.

The researchers found that compared with non-ICU patients, in ICU patients, markers of endothelial cell and platelet activation were significantly elevated, including von Willebrand Factor (VWF) antigen (mean, 565 percent in ICU patients versus 278 percent in non-ICU patients) and soluble P-selectin (15.9 versus 11.2 ng/mL). In 16 of 20 non-ICU patients, VWF antigen concentrations were also elevated above the normal range. Among all patients, there was a significant association between mortality and VWF antigen and soluble thrombomodulin. Soluble thrombomodulin concentrations greater than 3.26 ng/mL were associated with lower rates of hospital discharge (88 versus 52 percent) and a lower likelihood of survival (hazard ratio, 5.9).

Read the full HealthDay story.

See what experts have to say about the toll of the COVID-19 pandemic on mental health.

Will the COVID-19 Pandemic Leave a Mental Health Crisis in Its Wake?

MONDAY, July 6, 2020 (HealthDay News) -- Stressed from home-schooling your kids? Lonely from lockdown? Worried about a sick loved one isolated in a nursing home? Worried you might lose your job?

The ongoing COVID-19 pandemic is affecting everyone's mental health in ways small and large, and experts are concerned that for many, today's anxiety will become a tidal wave of mental health problems in the years ahead.

The pandemic is adding to what already was an underrecognized mental health crisis in the United States, according to Dr. Don Mordecai, national mental health and wellness lead at Kaiser Permanente in Oakland, Calif.

Read the full HealthDay story.

In a small study, all 10 patients who had severe COVID-19 symptoms produced T-cells that worked with antibodies to try to kill the virus and stop the infection.

How Immune System Fights COVID-19 May Be Key to Vaccine Success

MONDAY, July 6, 2020 (HealthDay News) -- Even the sickest COVID-19 patients make T-cells to fight the infection, a new study finds.

This means that a COVID-19 vaccine will have to cause the body to make T-cells along with antibodies, researchers say.

The immune response to the SARS-CoV-2 virus, which causes COVID-19, was the same in American and Dutch patients in the study.

Read the full HealthDay story.