For innate TEG maximum amplitude, sensitivity and negative predictive value were 100 percent.
TUESDAY, June 9, 2020 (HealthDay News) -- Hypercoagulable thromboelastography (TEG) can predict thrombotic events in patients with COVID-19 in the intensive care unit (ICU), according to a research letter published online June 5 in JAMA Network Open.
Jared Robert Mortus, M.D., from the Baylor College of Medicine in Houston, and colleagues conducted a retrospective electronic health record review for 21 patients admitted to the ICU with severe acute respiratory syndrome coronavirus 2 infection. Upon ICU admission, all patients underwent TEG and TEG with heparinase correction.
The researchers found that fibrinogen and dimerized plasmin fragment D levels were elevated in the patients. Nineteen patients (90 percent) demonstrated hypercoagulable TEG, including 14 and five patients with hypercoagulable TEG as defined by fibrinogen activity and maximum amplitude (MA) criteria and with hypercoagulable TEG as defined by MA criteria alone, respectively. Thirteen patients demonstrated clinical evidence of thrombotic events, with 46 events recorded (range, one to eight events/patient).