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Johnson & Johnson’s COVID-19 Vaccine Candidate Gets Fast-Tracked to Begin Phase 1/2a in July

Johnson & Johnson announced Wednesday that its investigational SARS-CoV-2 vaccine — known as Ad26.COV2-S, recombinant — will be fast-tracked to begin its Phase I/2a first-in-human clinical trial in the second half of July. Originally, it was scheduled to start in September.

The study will be held in the United States and Belgium, and it will be randomized, double-blind and placebo-controlled. Phase 1/2a will look at safety, the body's response to the vaccination and the immune response of the vaccine. The study will include 1,045 healthy adults between the ages of 18 and 55, plus adults who are 65 and older.

"Based on the strength of the preclinical data we have seen so far and interactions with the regulatory authorities, we have been able to further accelerate the clinical development of our investigational SARS-CoV-2 vaccine, Ad26.COV2-S, recombinant," said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer of Johnson & Johnson, in a press release.

If the vaccine is found to be safe and effective, Johnson & Johnson has committed to the goal of supplying more than one billion vaccine doses globally through the course of 2021.

Read the full press release.

HealthDay Now: Experts Discuss Cost, Safety, & Efficacy of New Alzheimer's Drug

In our latest HealthDay Now interview, Dr. Anton Porsteinsson, a principal investigator for the Biogen aducanumab trial, and Dr. Ken Lin, a primary care physician, discuss the controversial new Alzheimer's drug and whether it will provide any benefit to patients, despite its highly uncertain efficacy and steep cost.

Watch the in-depth discussion above, and see our past HealthDay Nows and other videos on our YouTube channel.

HD Live! Videos

HealthDay Now: Experts Weigh In On Alzheimer's Drug Controversy

HealthDay Now: Diabetes Care in 2021

HealthDay Now: Cancer Experts Share Highlights From Two Conferences

HealthDay Now: ASCO 2021 Highlights

In our latest HealthDay Now, Mabel Jong spoke with Dr. Lori Pierce, president of the American Society of Clinical Oncology and a cancer radiation specialist at the University of Michigan.

Dr. Pierce shared important takeaways from the recently concluded 2021 ASCO annual meeting and discussed why equity was the chosen theme this year.

Watch the in-depth discussion above, and see our past HealthDay Nows and other videos on our YouTube channel.

HealthDay Now: Why the COVID-19 Vaccine is Safe for Kids and How Vaccine Myths Impact Families

In our latest HealthDay Now, Dr. Hina Talib, a pediatrician and adolescent health specialist at the Children's Hospital at Montefiore, debunks myths and common concerns parents may have about giving their children Pfizer's COVID-19 vaccine, which was recently approved for use in children and teens ages 12 and up.

HealthDay Now's Mabel Jong also speaks with Alan Santee, a high school freshman from Massachusetts, about why he didn't hesitate to get vaccinated, and Ethan Lindenberger, a 20-year-old vaccine advocate from Ohio, about his experience having a mom who is anti-vaccine and how kids and parents can approach these conversations.

Watch the in-depth discussion above, and see our past HealthDay Nows and other videos on our YouTube channel.

HealthDay Now: The State of Mental Health and Post-COVID Stress Disorder

Watch our latest HealthDay Now to hear about the state of mental health and why many people fear returning to their social and work lives.

HealthDay's Mabel Jong spoke to Dr. Vivian Pender, president of the American Psychiatric Association, and Sherry Amatenstein, a social worker and therapist who has been dealing with these anxieties herself.

Watch the in-depth discussion above, and see our past HealthDay Nows and other videos on our YouTube channel.

HealthDay Now: American Association for Cancer Research Annual Meeting 2021 Recap

Watch our latest HealthDay Now as we recap the highlights of the American Association for Cancer Research (AACR) Annual Meeting 2021.

Mabel Jong from our liveblog team speaks with Dr. Antoni Ribas, former president of the American Association for Cancer Research and professor of medicine at UCLA, and Anna Plym, PhD, a postdoctoral research fellow at Brigham and Women's Hospital.

Watch the in-depth discussion above, and see our past HealthDay Nows and other videos on our YouTube channel.

HealthDay Now: The Latest on Multisystem Inflammatory Syndrome in Children (MIS-C)

Watch our latest HealthDay Now as we dive into the latest details on multisystem inflammatory syndrome in children (MIS-C).

Mabel Jong from our liveblog team speaks with Dr. Mary Beth Son, Program Director of Boston Children's Hospital's Rheumatology Program, and Brian Padla, father of James Padla, who has MIS-C.

Watch the in-depth discussion above, and see our past HealthDay Nows and other videos on our YouTube channel.


HealthDay Now: The COVID-19 Pandemic and Its Effects on the Mental Health of Children

Watch our latest HealthDay Now as we take a look at how living through the COVID-19 pandemic impacts children socially, mentally and emotionally.

One year in, this is their "new normal," but what does that mean for them? From social isolation to remote learning to a loss of structure and normalcy, we discuss how living during the pandemic has both short- and long-term effects on children.

Mabel Jong from our liveblog team speaks with:

  • Dr. Mark Reinecke, Department of Psychiatry & Behavioral Sciences, Northwestern University
  • Tracy Compton, a parent
  • Stephen Guerriero, a teacher
  • Jake Anderson, a student

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

HD Live!: Racial Disparities During the COVID-19 Pandemic and the Vaccination Rollout

Watch our latest HD Live! as we take a look at the COVID-19 pandemic and the vaccination rollout and how they've impacted people of color.

Mabel Jong from our liveblog team speaks with:

  • Tasha Clark-Amar, CEO, East Baton Rouge Council on Aging
  • Jill Ramirez, Executive Director, Latino HealthCare Forum (Austin)
  • Vickie Mays, PhD, Professor, UCLA Fielding School of Public Health

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

HD Live!: The Global COVID-19 Vaccination Rollout

Watch our latest HD Live! as we take a look at the global COVID-19 vaccination rollout and how the United States rollout compares.

Mabel Jong from our liveblog team speaks with Dr. Ran Balicer of Clalit Health Services and Dr. Arnold Monto of University of Michigan School of Public Health.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.