HealthDay Reports: Risk Score May Predict Critical Illness at COVID-19 Admission
Ten independent predictors in risk score include chest radiographic abnormality, age, hemoptysis and dyspnea.
Risk Score May Predict Critical Illness at COVID-19 Admission
TUESDAY, May 12, 2020 (HealthDay News) -- A risk score based on 10 factors can predict the risk for developing critical illness at COVID-19 admission, according to a study published online May 12 in JAMA Internal Medicine.
Wenhua Liang, M.D., from The First Affiliated Hospital of Guangzhou Medical University in China, and colleagues developed and validated a clinical score at hospital admission for predicting COVID-19 patients who will develop critical illness. Data were included from a retrospective cohort of 1,590 COVID-19 patients from 575 hospitals in China as of Jan. 31, 2020. Accuracy of the score was measured by the area under the receiver operating characteristic curve (AUC). The score was validated using data from four additional cohorts with 710 patients.
The researchers identified 10 variables as independent predictive factors from 72 potential predictors, and they were included in the risk score: chest radiographic abnormality (odds ratio, 3.39), age (odds ratio, 1.03), hemoptysis (odds ratio, 4.53), dyspnea (odds ratio, 1.88), unconsciousness (odds ratio, 4.71), number of comorbidities (odds ratio, 1.60), cancer history (odds ratio, 4.07), neutrophil-to-lymphocyte ratio (odds ratio, 1.06), lactate dehydrogenase (odds ratio, 1.002), and direct bilirubin (odds ratio, 1.15).