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A new clinical trial from the Washington University School of Medicine in St. Louis will look at the antidepressant fluvoxamine to see if the drug can be used as a potential treatment for COVID-19, according to a press release.

Fluvoxamine is an antidepressant and a selective serotonin-reuptake inhibitor (SSRI), and it's usually used to treat obsessive-compulsive disorder (OCD).

Caline Mattar, MD, an assistant professor of medicine in the Division of Infectious Diseases, explained in the press release how the two phases of COVID-19 are different and how this drug could help prevent the more life-threatening effects of the coronavirus.

"The first is caused by the viral infection itself, which gives people a fever and a cough and makes them feel ill, among other symptoms," Mattar said in the press release. "The information we have so far suggests that the second phase of the illness can involve a life-threatening inflammatory reaction — what we call a 'cytokine storm.' We want to learn whether fluvoxamine might help prevent that second phase of the illness."

The thought is that fluvoxamine could help relieve that overwhelming immune response that causes the cytokine storm. The trial would involve patients who are confirmed to have COVID-19 but who don't have severe enough symptoms to be put in a hospital.

Read the full press release.

Watch our latest HealthDay Now as we dive into the latest details on multisystem inflammatory syndrome in children (MIS-C).

Mabel Jong from our liveblog team speaks with Dr. Mary Beth Son, Program Director of Boston Children's Hospital's Rheumatology Program, and Brian Padla, father of James Padla, who has MIS-C.

Watch the in-depth discussion above, and see our past HealthDay Nows and other videos on our YouTube channel.


HD Live! Videos

Watch our latest HD Live! as we take a look at the global COVID-19 vaccination rollout and how the United States rollout compares.

Mabel Jong from our liveblog team speaks with Dr. Ran Balicer of Clalit Health Services and Dr. Arnold Monto of University of Michigan School of Public Health.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

UPDATE 1/26/21: Since our HD Live! interview with CEO Andrei Doroshin, the Philadelphia Health Department has severed its ties with the organization. The nonprofit has changed its status to a for-profit entity.

Watch our latest HD Live! as we take a look at Philly Fighting Covid, a nonprofit organization run by graduate students from Drexel University that aims to help with mass COVID-19 vaccination in Philadelphia.

Mabel Jong from our liveblog team speaks with Andrei Doroshin, founder of Philly Fighting Covid.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

Watch our latest HD Live! as we take a deep dive into the vaccine rollout across the country.

Mabel Jong from our liveblog team speaks with Dr. Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota and a member of the Biden COVID-19 Advisory Board.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

Watch our latest HD Live! as we take a deep dive into the latest information on the COVID-19 vaccines, including the rollout process, potential side effects, supply and distribution.

Mabel Jong from our liveblog team speaks with Dr. Paul Offit, Director of the Vaccine Education Center and an attending physician in the Division of Infectious Diseases at Children's Hospital of Philadelphia and one of the physicians on the FDA Vaccines and Related Biological Products Advisory Committee.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

Watch our latest HD Live! as we take a look back and a look ahead at COVID-19 and its impact on the United States and its healthcare workers.

Mabel Jong from our liveblog team speaks with Dr. David Shulkin, former Secretary of Veterans Affairs, ex-CEO of Beth Israel Medical Center in New York and an accomplished healthcare executive, and Dr. Joel Zivot, anesthesiologist and clinician at Emory University Hospital ICU.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

Watch our latest HD Live! with Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID).

Mabel Jong from our liveblog team speaks with Dr. Anthony Fauci about the latest on COVID-19, including the vaccines, the infection rates and the future.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

Our latest HD Live! is a conference wrap-up of the American Heart Association Scientific Sessions 2020.

Mabel Jong from our liveblog team speaks with Dr. Donald Lloyd-Jones, American Heart Association President-Elect, for a summary of the highlights of the AHA Scientific Sessions 2020.

Watch the in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.

Our latest HD Live! discussion is on how healthcare in America could be impacted by a Trump or Biden victory.

Mabel Jong from our liveblog team speaks with Marianne Udow-Phillips, director of the Center for Health and Research Transformation at the University of Michigan, and Brian Blase, who served as a healthcare adviser to President Trump from 2017-2019 and is now president and CEO of Blase Policy Strategies.

Watch our in-depth discussion above, and see our past HD Lives and other videos on our YouTube channel.